Babban birnin Djibouti shine birnin Djibouti. Shi ne birni mafi girma kuma babban birnin kasar Djibouti, wanda karamar kasa ce dake yankin kahon Afirka. Birnin Djibouti kuma shi ne babban tashar jiragen ruwa na Djibouti, wanda ke zama babbar cibiyar sufuri ga yankin. Ma'anar ƙamus na "babban birni" a cikin wannan mahallin yana nufin babban birni ko cibiyar gudanarwa na ƙasa inda gwamnati da wasu muhimman cibiyoyi suke.